Trifluoperazine

Drug Status in USA : Approved
Drug Status in Canada : Approved

pronunciation

pronounced as (trye floo oh per' a zeen)

Why is this medication prescribed?

Trifluoperazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Trifluoperazine is also used on a short-term basis to treat anxiety in people who have not been helped by other medications. Trifluoperazine is in a group of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.


How should this medicine be used?

Trifluoperazine comes as a tablet to take by mouth. It is usually taken one or two times a day. Take trifluoperazine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trifluoperazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of trifluoperazine and gradually increase your dose. Your doctor may decrease your dose once your symptoms are controlled.

Trifluoperazine may help control your symptoms, but it will not cure your condition. Continue to take trifluoperazine even if you feel well. Do not stop taking trifluoperazine without talking to your doctor. If you suddenly stop taking trifluoperazine, you may experience withdrawal symptoms such as nausea, vomiting, dizziness, and shakiness. Your doctor will probably want to decrease your dose gradually.


What are the precautions to be followed?

Before taking trifluoperazine,
  • tell your doctor and pharmacist if you are allergic to trifluoperazine; other phenothiazines such as chlorpromazine, fluphenazine, perphenazine, prochlorperazine (Compazine), promethazine (Phenergan), or thioridazine; or any other medications.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin); antidepressants; antihistamines; atropine (in Motofen, in Lomotil, in Lonox); barbiturates such as pentobarbital (Nembutal), phenobarbital (Luminal), and secobarbital (Seconal); diuretics ('water pills'); epinephrine (Epipen); guanethidine (not available in the US); ipratropium (Atrovent); lithium (Eskalith, Lithobid); medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, ulcers, or urinary problems; medications for seizures such as phenytoin (Dilantin); narcotic medications for pain; propranolol (Inderal); sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had liver disease or any condition that affects your blood cells, including conditions that affect the production of blood cells by your bone marrow. Your doctor may tell you not to take trifluoperazine.
  • tell your doctor if you have or have ever had pheochromocytoma (tumor on a small gland near the kidneys), breast cancer, glaucoma (condition in which increased pressure in the eyes can lead to gradual loss of vision), seizures, chest pain, or heart disease. Also tell your doctor if you plan to work with organophosphorus insecticides (a type of chemical used to kill insects) or if you have ever had to stop taking a medication for mental illness due to severe side effects.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking trifluoperazine, call your doctor. Trifluoperazine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trifluoperazine.
  • if you are having a myelogram (x-ray examination of the spine), tell your doctor and the radiographer that you are taking trifluoperazine. Your doctor will probably tell you not to take trifluoperazine for 2 days before the myelogram and for one day after the myelogram.
  • you should know that this medication may make you drowsy and may affect your thinking and movements, especially at the beginning of your treatment. Do not drive a car or operate machinery until you know how this medication affects you.
  • ask your doctor about the safe use of alcohol during your treatment with trifluoperazine. Alcohol can make the side effects of trifluoperazine worse.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Trifluoperazine may make your skin sensitive to sunlight.
  • you should know that trifluoperazine may make it harder for your body to cool down when it gets very hot. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat.
  • you should know that there is a small chance that people who handle trifluoperazine tablets will develop a skin rash. Anyone who helps you take your medication should avoid touching the tablets directly.

What are possible side effects of this medication ?

Trifluoperazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • drowsiness
  • dizziness
  • blurred vision
  • dry mouth
  • stuffed nose
  • nausea
  • difficulty urinating
  • widening or narrowing of the pupils (black circles in the middle of the eyes)
  • constipation
  • changes in appetite
  • weight gain
  • blank facial expression
  • shuffling walk
  • agitation
  • jitteriness
  • unusual, slowed, or uncontrollable movements of any part of the body
  • difficulty falling asleep or staying asleep
  • headache
  • extreme tiredness
  • weakness
  • breast enlargement
  • breast milk production
  • missed menstrual periods
  • decreased sexual ability in men
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
  • fever
  • muscle stiffness
  • confusion
  • fast or irregular heartbeat
  • sweating
  • yellowing of the skin or eyes
  • flu-like symptoms
  • sore throat, chills, and other signs of infection
  • neck cramps
  • tongue that sticks out of the mouth
  • tightness in the throat
  • difficulty breathing or swallowing
  • fine, worm-like tongue movements
  • uncontrollable, rhythmic face, mouth, or jaw movements
  • seizures
  • blisters
  • rash
  • hives
  • itching
  • swelling of the eyes, face, mouth, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
  • erection that lasts for hours
  • vision loss, especially in low light

Trifluoperazine may cause other side effects. Tell your doctor if you have any unusual problems while you are taking this medication.


How to store the medication and dispose it of after its use later?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.


Drug Category/Class

  • Phenothiazines
  • Phenothiazines With Piperazine Structure
  • Cytochrome P-450 CYP1A2 Inhibitors
  • Cytochrome P-450 CYP1A2 Inducers
  • Antipsychotic Agents
  • Psycholeptics
  • Dopamine Antagonists
  • Antiemetics
  • Nervous System
  • Adrenergic alpha-1 Receptor Antagonists
  • Phenothiazines with piperazine structure
Prescribed For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
Weight :407.496
Structure Trifluoperazine
Generic Drug Trifluoperazine prescribed For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
Formula

C21H24F3N3S

Trifluoperazine has 24 Brands listed


Dipicalm (5 mg)Elicalm (5 mg)
Espazine (1 mg)Espazine (5 mg)
Espazine Inj (10 mg)Flucalm (1 mg)
Gencalm (5 mg)Manocalm (10 mg)
Manocalm (2 mg)Manocalm (5 mg)
Neocalm (10 mg)Neocalm (5 mg)
Normacalm (5 mg)Psycalm (1 mg)
Psycalm (5 mg)Relicalm (5 mg)
Selocalm (10 mg)Selocalm (5 mg)
Sugil Inj (50 mg)Talecalm (10 mg)
Talecalm (5 mg)Trazine (10 mg)
Trazine (5 mg)Trinicalm (5 mg)

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